Effect of insect hormone, 20-hydroxyecdysone on growth and reproduction in mice
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The effects of 20-hydrosyecdysone (20-E) on growth and reproduction following daily intraperitoneal injections gave been studied in juvenile and adult mice of both sexes. The injections contained 0.1, 0.5 and 1.0mg of 20-E, which correspond to final doses from 2.8mg.g-¹ to 100 mg.g-¹; they were administered over a period of 30 days. The effects on growth were
evaluated by recording the daily increments of the living mass. In addition, the effects on female reproduction were determined by vaginal smears, while the effects on male reproduction were evaluated by size of seminal vesicles and by the content of sperm in caudal epididymis. It was found that 20-E enhanced growth in the groups of female juveniles but not in the male juveniles. In the adults, 20-E caused increased growth in both males and females. Due to pronounced cyclicity in female reproduction, the effects were more apparent in the males. These results, obtained by injetions of the purified compound, confirm previous conclusions regarding the anabolic-like action of ecdysteroids, which were reached principally by feeding the animals with a drug prepared from ecdysteroid-containing plants. Despite its anabolic-like effects on growth of seminal vesicles and decreased sperm production. These effects fo 20-E have been considered as potentially antiandrogenic. The profound disruption of sexual geat cycles in adult female mice provides strong presumptive evidence for the qualification of 20-E, and perhaps other ecdysteroids as well, into the category of various phytoestrogens. The possibility that 20-E could play a role as an essential sterolic vitamin is discussed.
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Bibliographic Details
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Main Author
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Pavel Stopka, 1968-
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Other Authors
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Jiří Štancl
Karel Sláma, 1934-
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Document Type
- Articles
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Physical Description
- Grafy.
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Published in
- Acta Societatis zoologicae Bohemicae. -- ISSN 1211-376X. -- Roč. 63, č. 3 (1999), s. 367-378
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Subjects
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Bibliography
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