Pharmacokinetics of ortho-I-hippurate in the blood and central lymph of the rat

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The authors studied ortho-I-hippurate kinetics in the blood and central lymph in two groups of intact rats and three groups of animals with induced pathological states (cirrhosis, uraemia, malabsorption). A differentiated lipid concentration in the central lymph was induced in intact animals by depriving them of food (the unfed group) or allowing them food (the fed group) before the experiment. All the hippurate kinetic parameters, including lymphatic bioavailability (FL), in the fed group were very close to those in the unfed group, which was also used as the control for the groups with induced pathological states. Cirrhosis, uraemia and malabsorption altered the blood and lymphatic kinetic parameters in many cases, but the changes mostly followed a parallel course so that FL was maintained (except in the uraemia group, in which it fell). … celý popis

Podrobná bibliografie

Hlavní autor

Jiří Lamka, 1953-

Další autoři

Š. Gallová

Typ dokumentu

Články

Fyzický popis

Grafy.

Publikováno v

Physiological research. -- ISSN 0862-8408. -- Roč. 40, č. 5 (1991), s. 543-548

Témata

fyziologie člověka

farmakokinetika

human physiology

pharmacokinetics

centrální lymfa > biologická dostupnost > central lymph > ortho-I-hippurate > bioavailibility

články

journal articles

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