The effect of sertindole on behavioural sensitisation to methamphetamine in mice
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Similarly to various other addictive substances, methamphetamine (Met) produces, following repeated application, a strong increase in behavioural responses (particularly locomotor behaviour), a phenomenon termed behavioural sensitisation. In our previous studies we tested the effects of various psychotropic drugs on behavioural sensitisation to Met, particularly
the effects of cannabinoid receptor ligands with different intrinsic activities and felbamate and memantine, antagonists of N-methyl-D-aspartate (NMDA) receptors. In the present study we investigated the influence of the antipsychotic drug sertindole (Srt) on sensitisation to the effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into 4 groups and were administered drugs seven times (from the 7th to 13th day of the experiment) as follows: (a) n1, 2: Met at the doses of 2.5 mg/kg/day; (b) n3: Met + Srt at the doses of 2.5 mg/kg/day + 10.0 mg/kg/day; (c) n4: Srt at the dose of 10.0 mg/kg/day. Locomotion in the Open field test was measured (a) after administration of vehicle on the 1st day, (b) after the 1st dose of drugs given on the 7th day, and (c) on the 14th day after the “challenge doses” administered in the following way: n1: Met; n2: Met+Srt, n3: Met; n4: Srt. We found the following significant behavioural changes: (1) a stimulatory influence of Met and development of sensitisation after repeated treatment (n1); (2) an inhibition of Met sensitisation in the case of a combined challenge dose of Met + Srt (n2); (3) a stimulatory effect of Met when animals were repeatedly pre-treated with Met + Srt (n3); (4) a significant inhibition of locomotion after the 1st dose of Srt, that persisted even after the last Srt dose (n4).
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Bibliographic Details
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Main Author
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Leoš Landa
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Other Authors
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Karel Šlais
Alexandra Šulcová, 1945-
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Document Type
- Articles
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Physical Description
- 4 il.
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Published in
- Veterinární medicína. -- ISSN 0375-8427. -- Roč. 57, č. 11 (2012), s. 603-609
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Subjects
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Item Description
- Grafy
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Bibliography
- Literatura na s. 608-609
