Využití moderních reverzních stacionárních fází na bázi oxidu zirkoničitého pro analýzu bioaktivních peptidů

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Separation of biologically active peptides was performed on polybutadiene (PBD) and polystyrene (PS) reversed phases based on zirconium dioxide. ZrO2 as an alternative carrier to silicagel offers ion-exchange interactions, which are useful for separation of ionizable compounds. The parameters like buffer concentration and pH, the amount of organic modifier and temperature affected separation of nonapeptides. The retention characteristics (retention factor, resolution, peak symmetry, separation efficiency) were investigated. The systems consisting of acetonitrile and phosphate buffer of basic pH were found suitable for separation of vasopressin-related peptides. … full description

Bibliographic Details

Other Authors

Lucie Janečková, Jana Sobotníková, Eva Tesařová, Zuzana Bosáková

Document Type

Articles

Physical Description

11 il.

Published in

Chemické listy. -- ISSN 0009-2770. -- Roč. 104, č. 5 (2010), s. 334-342

Subjects

biologicky aktivní peptidy > analýza

kapalinová chromatografie

bioactive peptides

liquid chromatography

bioaktivní peptidy > oxid zirkoničitý

Item Description

6 obrázků, 5 tabulek
Anglické resumé

Bibliography

Literatura